Protein | Phyre2 Virulence Model Templates (% confidence / % coverage) | Roles in virulence | Expression Analyses | MSC | |
---|---|---|---|---|---|
cDNA/DNA | Protein | ||||
TPANIC_0020 | • TgMIC2 (Toxoplasma gondii micronemal protein 2 A/I domain) (98.2 / 21.2) | • Promotes active invasion [80] | 2.206 | E [47] | - |
• TRAP protein (Plasmodium vivax) (98.1 / 21.9) | • Cell adhesion & invasion [81] | ||||
TPANIC_0126 | • Outer membrane protein W (E. coli) (97.3 / 72.2) | • Phagocytosis resistance [82] | 1.115 | E [47] | + |
• Outer membrane protein A (E. coli) (94.8 / 64.1) | • Host adhesion, invasion and immune evasion [83] | ||||
• Outer membrane protein OprG (Pseudomonas aeruginosa) (93.9 / 70.0) | • Cytotoxicity [84] | ||||
• Outer membrane protein F (P. aeruginosa) (92.8 / 51.1) | • Host adhesion [85] | ||||
• NspA (Neisseria surface protein A) (90.4 / 64.1) | • Factor H-binding and complement resistance [86] | ||||
TPANIC_0134 | • Bacterial sialidases/neuraminidases (Micromonospora viridifaciens, Vibrio cholera, Parabacteroides distasonis, Bacteroides thetaiotaomicron, Streptococcus pneumoniae) (98.9-99.4 / 69.4-72.3) | • V. cholera; facilitates cholera toxin cell binding and penetration [87] | 3.586 | ND | + |
• S. pneumoniae; host cell glycan damage promotes colonization of respiratory tract [88, 89] | |||||
TPANIC_0225 | • Leucine-rich repeat surface proteins (Eubacterium ventriosum, Faecalibacterium prausnitzii, Bacteroides species) (99.9-100 / 72.4-83.3) | • Host adhesion [90] | 2.27 | ND | - |
• PcpA (S. pneumoniae choline-binding protein) (100 / 99.6) | • Host adhesion [91] | ||||
TPANIC_0246 | • TRAP protein (P. vivax) (99.9 / 35.7) | • Cell recognition & invasion [81] | 0.096 | E [47] | - |
• TRAP protein (Plasmodium falciparum) (99.8 / 35.8) | • Cell recognition & invasion [81] | ||||
 | • TgMIC2 (T. gondii micronemal protein 2 A/I domain) (99.8 / 30.5) | • Active invasion [80] |  |  |  |
TPANIC_0421 | • PknD (Mycobacterium tuberculosis serine/threonine protein kinase, extracellular domain) (99.9 / 37.6) | • Adhesion and invasion of brain endothelia [92] | 0.686 | E [47] | - |
TPANIC_0544 | • SmcL (Listeria ivanovii Sphingomyelinase-C) (99.9 / 51.9) | 0.811 | E [47] | - | |
• Beta-hemolysin toxin (Staphylococcus aureus) (99.9 / 51.4) | • Cytotoxicity [95] | ||||
• Cytolethal distending toxin protein B (S. enterica, Haemophilus ducreyi) (99.9 / 51.9-52.1) | • Cytotoxicity [96] | ||||
TPANIC_0579 | • YenC2 (Yersinia entomophaga ABC toxin; BC component) (93.8 / 36.8) | • Cytotoxicity [97] | 0.268 | E [47] | - |
TPANIC_0594 | • HP1028 (Helicobacter pylori lipocalin) (100 / 64.8) | 2.238 | ND | + | |
TPANIC_0598 | • BamB (Moraxella catarrhalis Beta barrel assembly machinery protein B) (97.9 / 56.3) | • BAM complex; assembly and insertion of beta-barrel proteins in outer membrane [100, 101] | 0.272 | E [47] | - |
TPANIC_0625 | • BamD (Beta barrel assembly machinery protein) (Rhodothermus marinus, E. coli) (95.9-97.0 / 27.6-46.8) | • Essential BAM complex protein; assembly and insertion of beta-barrel proteins in outer membrane [102] | 0.461 | E [47] | - |
TPANIC_0733 | • NspA (Neisseria surface protein A) (97.8 / 58.4) | • Factor H-binding and complement resistance [86] | 1.735 | ND | + |
• Ail (Yersinia pestis attachment invasion locus protein) (93.6 / 64.4) | • Host cell attachment, invasion, and complement resistance [103,104,105] | ||||
TPANIC_0783 | • BamB (E. coli Beta barrel assembly machinery protein B) (96.2 / 24.7) | • BAM complex; assembly and insertion of beta-barrel proteins in outer membrane [100, 101] | 0.402 | ND | - |
TPANIC_0789 | • LolA (P. aeruginosa outer- membrane lipoprotein carrier/localization protein) (99.5 / 86) | • Translocation of lipoproteins to the outer membrane [106, 107] | 1.283 | - | |
• LprG (M. tuberculosis lipid- binding protein (96.8 / 71.7) | • TLR2-agonist; inhibits primary human macrophage MHC-II Ag processing [108] | ||||
TPANIC_0854 | • Bacterial sialidases/neuraminidases (M. viridifaciens, V. cholera, P. distasonis, B. thetaiotaomicron, S. pneumoniae, P. aeruginosa) (98.9-99.5 / 17.0-25.8) | • V. cholera; facilitates cholera toxin cell binding and penetration [87] | 0.221 | E [47] | - |
• S. pneumoniae; host cell glycan damage promotes colonization of upper respiratory tract [88, 89] | |||||
TPANIC_0911 | • EscU (E. coli type 3 secretion system protein) (100 / 96.4) | • Type 3 effector translocation into host cells [109] | 0.701 | ND | - |
• SpaS (Shigella flexneri type 3 secretion system protein) (99.9 / 94.0) | • Invasion and secretion of invasion plasmid antigens [110] | ||||
TPANIC_0928 | • SurA (E. coli chaperone) (100 / 84.0) | • Folding and assembly of outer membrane proteins [101] | 1.049 | E [47] | - |
TPANIC_0966 | • TolC (E. coli outer membrane channel protein) (100 / 79.4) | 0.856 | ND | - | |
TPANIC_0967 | • TolC (E. coli outer membrane channel protein) (99.0 / 85.7) | 2.844 | E [47] | + | |
TPANIC_0968 | • TolC (E. coli outer membrane channel protein) (98.8 / 85.2) | 3.256 | E [47] | + | |
TPANIC_0969 | • TolC (E. coli outer membrane channel protein) (99.0 / 87.0) | 2.751 | + |