From: Crystal structures of the human Dysferlin inner DysF domain
Stack | Dysferlin inner domain | W/R type | Interactions | Myoferlin inner domain equivalent (Residue mentioned in interaction) | Outer Dysferlin DysF equivalent |
---|---|---|---|---|---|
1 | R1048 | Aliphatic W992 | Planar interaction to Y1034 in crystal contact | K1029 | P1100 |
 |  |  | H Bond to Q1010 in crystal contact |  |  |
 |  |  | Interacts with crystallisation phosphate |  |  |
 |  |  | Guanadinium Beyond NH/CZ of W992 |  |  |
1 | W992 | Â | H bonds to crystallisation phosphate | W973 | W924 |
1 | R1046 | Perpendicular W992 | NH points to 6 membered ring of W992 | R1027 | R1096 |
 |  |  | H bonds to crystallisation phosphate |  |  |
 |  |  | H bond to E951 | (D392) | (A879) ?E880 |
2 | C988 | Â | H bond to 5 membered ring of W994 | C969 | P920 |
 | W994 |  |  | W975 | W926 |
 | R1044 | Planar W994/ Aliphatic W999 | Planar stack above 5 membered ring W994 | R1025 | R1096 |
2 | W999 | Â | R1044 guanadinium is beyond NE/CZ edge | W980 | W930 |
 |  |  | Aliphatic interaction with side chain of K983 |  |  |
2 | K983 | Â | Just over 4Â Ã… above 6 membered ring of W1042 | P964 | K915 |
2 | W1042 | Â | H bond to E955 | L1023 (Q936) | W1094 (E883) |
3 | R1040 | Aliphatic W1012 | H bond to E955 | R1021 (Q396) | R1092 (E883) |
 |  |  | Guanadinium Beyond NE-CZ of W1012 |  |  |
3 | W1012 | Â | Â | W993 | W1069 |
3 | R1038 | Planar W1012 | Planar stack to 5 membered ring of W1012 | R1019 | R1090 |
 |  | Planar W965 | Planar stack to 5 membered ring of W965 |  |  |
3 | W965 | Â | H bond to major conformation of E1031 | W946 (E1012) | W894 |
3 | R959 | Aliphatic W965 | Guanadinum Beyond NE-CZ of W965 | R940 | K887 |
 |  |  | H bonds to major and minor conformations of E1031 |  |  |
Opposite Face | F954 | Â | Â | Y935 | Y882 |
 | R1039 | Planar F954 | Close to planar Stack above F954 | R1020 | R1090 |
 |  | Planar W1027 | H bond to E1013 | (E994) | (E1070) |
 |  |  | Planar Stack above 5 membered ring of W1027 closer to NE than centre |  |  |
 | W1027 |  |  | W1008 | Unclear |