Figure 1From: Structural insights into Resveratrol’s antagonist and partial agonist actions on estrogen receptor alpha Variation of dynamic parameters of ERα bound to different ligands obtained from MD stimulation. (A) Variations in Cα-RMSD of ERα monomer with simulation time. RES-ERantgonist, DES-ER and ICI-ER have highly stable complexes during simulation (cyan, black and orange), RES-ERagonist and 4OHT-ER show high fluctuations (green, red). (B) RMSF profile of RES-ERα monomer. Black and red lines represent RES bound ERα in agonist and antagonist conformation, respectively. The peak in fluctuation corresponds to Helices 8 & 9 (residues 150 to 166).Back to article page